4:30pm - 5:30pm
Room 209 Havemeyer
New York, NY 10027
Cationic polymers possessing ammonium groups have been investigated as antimicrobial and gene transfection agents. Polycations containing primary, secondary, tertiary or quaternary amino groups have been used for gene complexation and delivery, due to their ability to form electrostatic complexes with DNA under physiologic conditions. Biodegradable polycations based on spermine, a natural oligoamine grafted on dextran, have also been synthesized. These spermine-dextran conjugates are relatively non-toxic and possess high transfection yield in vitro and in vivo. Antimicrobial quaternary ammonium-bearing nanoparticles were synthesized and shown to possess antimicrobial activity against a range of oral pathogens. In this talk I will discuss the synthesis and applications of these cationic polymers in therapeutics.
Thursday, August 3, 2017 at 4:30pm
Room 209 Havemeyer Hall
MiMs! Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, NY 10027, USA | 212-854-2202 | http://chem.columbia.edu/