5:30pm - 6:30pm
The Miller Room 328 Havemeyer
New York, NY 10027
Abstract: Single-molecule biophysical techniques face trade-offs between experimental factors such as temporal resolution, signal-to-noise ratio, and invasiveness that may limit the information that they can provide. In this talk I will discuss the development of a carbon nanotube (CNT)-based single-molecule technique using field-effect transistors (smFET) and the use of this label-free, high-time-resolution technology to provide information that compliments that available from other biophysical techniques. In particular I will focus on smFET studies of (1) DNA hybridization and (2) the folding dynamics of a class of metabolite-sensing RNA molecules known as riboswitches. Predominantly found in bacteria, riboswitches are genetic control elements that show promise as targets for next-generation antibiotics and as engineering tools in the field of synthetic biology.
Tuesday April 12, 2016 at 5:30pm
Miller Room 328 Havemeyer
Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, NY 10027, USA | 212-854-2202 | www.columbia.edu/cu/chemistry