Michelle Ziperstein (Kaufman Group)
5:30pm - 6:30pm
The Miller Room 328 Havemeyer
Metastatic breast cancer is dangerous due to the ability of cells within a primary tumor to breach the surrounding basement membrane, invade through dense collagen I-rich breast tissue, and reach distant organs where secondary tumors are formed. Previous studies have begun to explore connections between the invasive capacity of breast cancer cells, gene expression profiles, and their aggregate morphologies in 3D environments. To further assess whether morphology can be used as a predictor of invasive capacity, six cell lines were evaluated for their ability to invade in various contexts. We found that although morphology alone was insufficient to predict how well cells invaded in each of these assays, the 3D spheroid invasion assay shows potential as an inexpensive functional method to predict breast cancer invasive capacity.