Our group deals with structural aspects of bioactive compounds and their mode of action. In most cases this involves investigating the interaction of small molecules with their biopolymeric receptors. We also continue to pursue isolation and characterization of natural products that are challenging because of their extremely limited quantity, instability, etc. Parallel with these studies, we place emphasis on developing new methods to facilitate structural studies, including biopolymers, as well as small molecules and new isolation methods.
A chemistry unit with two newly constructed laboratories has recently started in Biosphere 2 in Arizona. The world in this huge glass-domed building with its rain forest, savannah, and ocean constitutes an unprecedented “Nature” with no ultraviolet light, and is bound to lead to new natural products chemistry.
Preparation of Ginkgolide and F-seco-ginkgolide Lactols: the unique Reactivity of a-Hydroxy Lactones toward Na BH4, K. Tanaka, K. D. Kester, N. Berova and K. Nakanishi, Tetrahedron Lett., 46, 531-534 (2005)
Ginkgo Biloba, K. Stromgaard and K. Nakanishi. Encyclopedia of Dietary Supplements, Marcel Dekker, 249-257 (2005)
Synthesis and Circular Dichroism of Tetraarylporphyrin-Oligonucleotide Conjugates, M. Balaz, A.E. Holmes, M. Benedetti, P.C.Rodriguez, N. Berova, K. Nakanishi, G. Proni, J. Am. Chem.. Soc., 127, 4172-4173 (2005)
Fluorescence Detected Exciton Coupled Circular Dichroism: Development of New Fluorescent Reporter Groups for Structural Studies, K. Tanaka, G. Pescitelli, K. Nakanishi, N. Berova, Monatshefte f. Chemie, Chemical Monthly, 136, 367-395 (2005)
Chiral Recognition of Cyclic a-Hydroxyketones by CD-Sensitive Zinc Tetraphenylporphyrin Tweezer, H. Ishii, Y. Chen, R.A. Miller, S. Karady, K. Nakanishi, H. Berova, Chirality, 17, 305-315 (2005)
Comparative Study of Energy-Transfer Processes in Several Porphyrin-Based Artificial Light-Harvesting Molecules, R. Hausschild, G. Riedel, J. Zeller, T.S. Balaban, V.I. Prokhorenko, H. Kalt, N. Berova, X. Huang, R. Pesticelli, K. Nakanishi, J. Luminescence, 112, 454-457 (2005)
Effect of Elevated Atmospheric CO2 on Oviposition Behavior in Manduca sexta Moths, L. Abrell, P. G. Guerenstein, W.L. Mechaber, G. Stange, T.A. Christensen, K. Nakanshi and J.G. Hildebrand, Global Change Biology, 11, 1-11 (2005)
Isolation and Characterization of a Retinal Pigment Epithelial Cell Fluorophores: An All-trans-retinal Dimer Conjugate, N.E. Fishkin, J.R. Sparrow, R. Allikmets, K. Nakanishi, Proc. Natl. Acad. Sci., 102, 7091-7096 (2005)
Anthocyanins protect against A2E Photooxidation and Membrane Permeabilization in Retinal Pigment Epithelian Cells, Y. P. Jang , J. Zhou, K. Nakanishi, J.R. Sparrow, Photochem. Photobiology, 81, 529-536 (2005)
A Cationic Zinc Porphyrin as a Chiroptical Probe for Z-DNA, M. Balaz, M. De Napoli, A. E. Holmes, A. Mammana, K. Nakanishi, N. Berova , R. Purrello, Angew. Chem. Int. Ed., 41, 4006-4009 (2005)